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Research at Bioclinicum

BioClinicum brings together research groups from Karolinska Institutet within six research themes with a focus on preclinical research.

The research groups are linked to Karolinska University Hospital's medical units and collaborate with the healthcare sector to translate new research results into treatments and new diagnoses.

BioClinicum research groups

The BioClinicum hosts up to 100 research groups divided into themes that reflect their research focus.

The Children, Women and Genetics research theme conducts translational research in women's and children's health and genetic diseases and conditions. The research focuses on understanding disease mechanisms and human development at a molecular level and applying new knowledge in healthcare for better diagnosis and treatment.

Research theme leader Kristiina Tammimies»

Agneta Nordenskjöld's research group "Malformation Genetics" studies the molecular background and long-term effects of impaired sexual development and bladder exstrophy.

Angelica Lindén Hirschberg's research group studies basic hormonal and genetic links between metabolism and reproduction in women. The overall goal is to improve diagnostics, fertility and long-term health.

Anna Nilsson's research group is investigating in detail, ex vivo and in vitro, how chemotherapy affects the child's immune response to infections.

Cilla Söderhäll's research group wants to increase the understanding of the molecular mechanisms that contribute to asthma and allergic diseases in children. The goal is to develop molecular tools that can be used as a complement to everyday clinical practice.

The Jan-Inge Henter/Nikolas Herold research group belongs to the field of pediatric cancer and is represented by two subgroups in BioClinicum:
Frida Holm studies how epitranscriptomic regulation contributes to cancer stem cell renewal in acute lymphoblastic leukemia.
Nikolas Herold conducts translational pediatric cancer research on resistance to chemotherapy and immunotherapy to develop new treatments.

Lars Sävendahl's research group studies bone growth with the aim of developing methods to treat children and adolescents with abnormal height growth.

Klas Blomgren's research group (only in swedish) studies aim to develop protective treatment and strategies to stimulate healing after injuries in the growing brain.

Clinical Genetics is led by Richard Rosenquist Brandell and studies genetic diseases at the molecular level in a translational research environment. Our overall goal is to better understand underlying disease mechanisms, apply new knowledge in genetic diagnostics, improve prognosis assessment and develop new treatment strategies.

Kristiina Tammimie's research group studies how genetic factors contribute to the emergence of neuropsychiatric disabilities (NPF) and how these factors translate into biological networks that affect brain development.

Kristina Gemzell Danielsson research group studies reproductive health through translational research "From Bench-to-Bed-to the Hands of Women". The experimental research focuses on the endometrium including embryo implantation and the link between endometriosis and cancer.

Magdalena Fossum's research group focuses on tissue engineering in reconstructive surgery for children with congenital malformations such as too small bladder, too short urethra or lack of vagina. We also perform molecular studies on wound healing in the urinary tract and genitalia, both in healthy and diseased tissue to improve healing after surgery.

NORDFERTIL Research Lab led by Jan-Bernd Stukenborg and focuses on pluripotent stem cells and novel invitro systems for the development and differentiation of male gametes.

Rare Diseases led by Ann Nordgren and Anna Lindstrand study rare dieases both clinically and at the molecular level to improve genetic diagnostics, increase knowledge of genotype-phenotype correlations and understand more about the biological mechanisms leading to disease.

Ulrika Åden's research group (only in swedish) studies how the brain develops in children who have been critically ill as newborns.

The Cancer research theme focuses on cancer and related diseases. Mainly studies to identify new treatment strategies but also to develop methods for diagnosis, prognosis and precision medicine. Research theme leader: Andreas Lundqvist.

Andreas Lundqvist's research group studies tumor immunology with a focus on understanding mechanisms for how solid tumors evade the immune system.

Anders Österborg and Håkan Mellstedt's research group aims to develop chemotherapy-free precision treatment for lymphoid malignancies with a focus on chronic lymphocytic leukemia (CLL) and B-cell lymphoma.

Anita Göndör's research group studies the interplay between genome organization and metabolism in complex diseases such as cancer.

Arne Östman's research group aims to better understand the interaction in the tumor microenvironment between malignant cells, fibroblasts, vessels and immune cells.

The Children's Tumor Bank is a national sample collection and genomic biobank infrastructure that promotes research on childhood solid tumors.

Catharina Larsson's research group studies the origin and malignification of tumors in endocrine organs with a focus on genetic predisposition, early and late events and their impact on cell function and the natural course of the diseases.

Cecilia Söderberg Naucler's research group studies microbial pathogenesis.

Georgios Rassidakis' research group studies lymphoma and leukemia with a focus on, among other things, immunological anti-tumor mechanisms.

Johan Hansson's research group conducts research in the tumor disease malignant melanoma. The group conducts translational research aimed at improving prevention and treatment options.

John Inge Johnsen and Per Kogner's research group consists of four subgroups, all of which conduct research aimed at mapping and understanding the molecular signaling and biology of cancer cells in the childhood cancers neuroblastoma and medulloblastoma.

Jonas Bergh's research group studies breast cancer to better understand and predict each patient's unique drug sensitivity, improve survival and avoid treatment-related toxicity.

Katja Pokrovskaya's research team focuses on finding new targeted cancer therapies to overcome drug resistance.

Klas Wiman's research group conducts research in molecular cell biology, tumor biology and novel cancer therapy. His main interest is the function and regulation of the tumor suppressor p53.

Lars Holmgren's research group's focus is on understanding the mechanisms for the formation of new blood vessels in order to identify new treatment options for cancer diseases.

Lars Ährlund-Richter's research group

Leonard Girnita's research group studies the interaction between receptor tyrosine kinases (RTKs) and G protein-coupled receptors (GPCRs) with the aim of finding new methods for the diagnosis and treatment of cancer.

Linda Lindström's research group studies factors for early and late metastasis of cancer tumors.

Martin Enge's research group studies gene regulation and cell interactions in cancer via the development of new cell-based technologies.

Malin Wickström's research group studies the underlying molecular mechanisms for the development of neuroblastoma.

Monica Nistér's research group studies cellular and molecular pathology.

Ninib Baryawno's research group is part of Per Kanger's team where the research focus is on improving the treatment of various cancers in both adults and children.

Olle Larsson's research group studies the insulin-like growth factor 1 receptor (IGF-1R) and its role in cancer cell growth.

Pär Nordlund's research group has developed the Cellular Thermal Shift Assay (CETSA) method that can investigate how proteins interact with drugs or other molecules in living cells. The method is now being used with the aim of improving cancer treatments.

Rolf Kiessling's research group is studying a new generation of cancer treatments based on immunotherapy to activate and target the body's own immune system against cancer.

Simon Ekman's research group aims to find new biomarkers for the diagnosis and treatment of cancers, particularly in the lungs.

Sten Nilsson's research group

Thuy Tran's research group focuses on developing radioactive tracers for precision diagnosis, treatment and monitoring of oncological diseases.

Tina Daliani's research group studies human papillomavirus (HPV) and specific markers to tailor targeted treatment for head and neck cancer and pediatric cancer.

Xu Dawei's research group

Yvonne Brandberg's research group focuses on investigating and improving people's experiences of being screened for, diagnosed with, and treated for various cancers.

The research theme Inflammation and Infection focuses on inflammatory diseases, allergy and infectious diseases where they study immunological mechanisms. A major research focus within the theme is respiratory infections. Research theme leader: Åsa Wheelock.

Anders Lindén's research group focuses on immune signaling in patients with chronic airway obstruction with the aim of finding new biomarkers and developing individualized follow-up and treatment.

Anna Färnerts research group studies malaria with a focus on antigen diversity, biomarkers, immunological memory and long-term effects of infection.

Gunnar Nilsson's research group studies the mast cells of the immune system and their role in health and disease. The research focus is on understanding regulated mechanisms for activation, among other things.

Johan Grunewald's research group studies the immunological/inflammatory mechanisms underlying the lung diseases asthma, COPD and sarcoidosis. The focus is on identifying factors of importance for the development of inflammation.

Karin Loré's research group wants to understand in detail how the immune system reacts to vaccination in order to contribute to new more effective vaccines with fewer side effects.

Kristina Broliden's research group studies human mucosal immunology with a focus on the disease HIV.

Lars-Olof Cardell's research group studies allergy and hyposensitization.

Magnus Sköld's research group uses well-characterized patient cohorts and laboratory techniques to study respiratory diseases.

Marinanne van Hage's research group aims to increase the understanding of allergic diseases and develop new strategies for allergy vaccination.

Muhammad Asgar's research group studies the relationship between infection and ageing.

Anna Smed Sörensen's research group aims to increase understanding of the function/dysfunction of immune cells in the airways and lungs in various lung diseases.

Susanne Gabrielsson's research group seeks effective exosome-based therapies for cancer, allergies and autoimmune diseases. The research also aims to improve methods for detecting cancer and lung diseases.

Taras Kreslavskiy's research group is focused on immunology, with a specific focus on the mechanisms used by lymphocytes to determine the fate of a cell.

Åsa Wheelock's research group studies inflammatory lung disease by integrating information from multiple molecular levels (mRNA, miRNA, protein and metabolites) with clinical characterization.

The Cardiovascular research theme focuses on mechanisms related to heart attack, stroke, aneurysm, heart failure, thromboembolism, metabolism, inflammatory disease and diabetes. They also participate in many translational networks aimed at improving treatment outcomes. Research theme leader: Peder Olofsson.

Anneli Björklund's research group´studies diabetes at the Unit of Experimental and Clinical Neuroendocrinology.

Francesco Cosentino's research group studies the molecular and cellular processes underlying vascular and cardiac dysfunction in obesity and diabetes.

John Pernow's team studies aim to explore the underlying mechanisms of atherosclerosis and the development of new therapeutic strategies to reduce the risk of heart attack.

Jovan Antovic's research group is active in the field of coagulation and clinical chemistry, studying microparticles and the relationship between coagulation and inflammation.

Lars Maegdefessel's research group studies vascular disease with a focus on non-coding RNA and its potential as a biomarker and in the development of new treatments.

Ljubica Matic's research group is active in the field of vascular surgery and studies, among other things, carotid artery calcification.

Peder Olofsson's research group studies the nervous system's regulation of immunological mechanisms in the field of bioelectronic medicine.

Per Eriksson's research group investigates underlying mechanisms of aortic aneurysm with the aim of understanding the clinical course, identifying biomarkers for the disease and elucidating the pathogenic mechanisms.

Roland Nilsson's research group specializes in detailed analysis of cellular metabolism. The research aims at a deeper and more quantitative understanding with a particular interest in the metabolic disorders that occur in cancer cells.

Sergiu Bogdan Catrina's research group is active in the field of growth and metabolism with a focus on bone metabolic diseases, diabetes and hypothyroidism.

Ulf Hedin's research group studies mechanisms in the development of peripheral vascular disease and biological processes in the vessel wall during vascular surgery for benign arterial disease, stroke and aneurysm.

The Neuro research theme focuses on psychiatric and neurological diseases and brain and spinal cord injuries. The theme's research groups study disease mechanisms with the aim of developing better diagnostics and discovering new or improved treatments for brain tumors, stroke, brain and spinal cord injury, multiple sclerosis, Parkinson's disease and other movement disorders. We conduct both research and teaching in close collaboration with the clinical activities at Karolinska University Hospital. Research theme leader: Per Svenningsson.

Karima Chergui's research group investigates and identifies neuronal changes in Parkinson's disease. The group also focuses on understanding the mechanisms that lead to rapid and long-lasting antidepressant effects of ketamine.

Lars Larsson's research group studies basic and clinical muscle biology with a focus on the underlying mechanisms of impaired muscle function in aging and primary and secondary myopathies.

Lou Brundin's research group studies the impact of stem cells on inflammation in the nervous system and its link to disease.

Mikael Svensson's research group is active in the field of neurosurgery with projects aimed at developing new techniques for treating injuries or diseases of the central nervous system.

Per Svenningsson's research group studies movement disorders, specifically Parkinson's disease, and depression. The aim is to understand the molecular mechanisms behind the disease states and to identify new biomarkers and treatments.

Staffan Holmin's research group works with clinical and translational research in several fields related to modern neuroimaging, nuclear medicine and vascular interventions.

The Ageing research theme studies Alzheimer's disease and other neurodegenerative diseases as well as brain and spinal cord injuries. The focus is on identifying the molecular basis of the pathology. Research theme leader: Helena Karlström.

Andre Fisahn's research group studies mechanisms of neuronal synchronization and functional dynamics in neuronal networks.

Bengt Winblad's research group has the main research area of clinical evaluation and treatment of dementia, especially Alzheimer's disease.

Caroline Graff's research group studies the genetics and neuropathology of neurodegenerative diseases, specifically Alzheimer's disease and FTLD and FTLD associated with amyotrophic lateral sclerosis (ALS).

Erik Sundström's research group is working on the development of cell therapy for spinal cord injury with a focus on the treatment of post-traumatic syringomyelia (PTS).

Helena Karlström's research group is studying CADASIL, a condition that leads to stroke and dementia. The research aims to better understand the molecular mechanisms and develop treatment.

Jaan-Olle Andressoo's research group is developing new animal models that can up- and down-regulate the expression of important genes in psychiatric and neurodegenerative diseases.

Lars Tjernberg's research group studies at the molecular and subcellular level the causes of the development of Alzheimer's disease.

Linus Jönsson's research group studies health economics and neurodegenerative diseases such as Alzheimer's disease.

Maria Ankarcrona's research group studies the mechanisms of cell degeneration in Alzheimer's disease. Research is focused on the role of mitochondria and organelles in these processes.

Marianne Schultzberg's research group focuses on the mechanisms of inflammation in neurodegenerative diseases such as Alzheimer's disease, with the aim of identifying new treatment strategies.

Per Nilsson's research group studies the role of non-functioning autophagy in Alzheimer's disease with the aim of finding new treatment strategies.

Silvia Maioli's research group focuses on understanding the biological mechanisms behind risk factors for Alzheimer's disease and aging.

Akademiska stråket 1
171 64 Solna